Journal
BIOMATERIALS
Volume 26, Issue 22, Pages 4495-4506Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.11.046
Keywords
thiol-acrylate polymerization; in situ cross-linking; photopolymerization; hydrolytic degradation; poly(ethylene glycol)
Funding
- NIDCR NIH HHS [R01 DE12998] Funding Source: Medline
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Degradable thiol-acrylate photopolymers are a new class of biomaterials capable of rapidly polymerizing under physiological conditions upon exposure to UV light, with or without added photoinitiators, and to depths exceeding 10 cm. These materials are formed in situ, and the versatility of their chemistry affords a high degree of control over the final material properties. For example, variations in monomer mole fractions directly affect the final network molecular structure, varying the time required to achieve complete mass loss from 25 to 100 days, the molecular weight distributions of the degradation products, and the swelling ratios and compressive moduli throughout degradation. Additionally, varying the mole fraction of multifunctional thiol monomer in the initial reaction mixture controls the concentration of reactive sites in the network available for post-polymerization modification of the polymer. (c) 2004 Elsevier Ltd. All rights reserved.
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