Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 75, Issue 24, Pages 7866-7869Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01942-09
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- BMBF [0315239A]
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In the present work, lysine production by Corynebacterium glutamicum was improved by metabolic engineering of the tricarboxylic acid (TCA) cycle. The 70% decreased activity of isocitrate dehydrogenase, achieved by start codon exchange, resulted in a > 40% improved lysine production. By flux analysis, this could be correlated to a flux shift from the TCA cycle toward anaplerotic carboxylation.
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