Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 75, Issue 22, Pages 7291-7293Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01402-09
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Funding
- 21C Frontier Microbial Genomics and Application Center Program
- Ministry of Science and Technology, Republic of Korea [11-2008-14-007-00]
- National Research Foundation of Korea [11-2008-14-007-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Putative hopanoid genes from Streptomyces peucetius were introduced into Escherichia coli to improve the production of squalene, an industrially important compound. High expression of hopA and hopB (encoding squalene/phytoene synthases) together with hopD (encoding farnesyl diphosphate synthase) yielded 4.1 mg/liter of squalene. This level was elevated to 11.8 mg/liter when there was also increased expression of dxs and idi, E. coli genes encoding 1-deoxy-D-xylulose 5-phosphate synthase and isopentenyl diphosphate isomerase.
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