Journal
DIGESTIVE AND LIVER DISEASE
Volume 37, Issue 8, Pages 547-558Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2005.04.001
Keywords
functional dyspepsia; gastroduodenal dysfunction; H. pylori; brain-gut axis; psychosocial factors; health seeking behaviour; post infective
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Functional dyspepsia is far more common than dyspepsia due to organic disease, both in the community and general practice. Proposed aetiopathogenic factors include gastric acid, Helicobacter pylori infection, delayed emptying, hypersensitivity or impaired accommodation of the stomach, dysfunction of the duodenum or brain-gut axis, psychosocial morbidity and post-infective mucosal damage. More effective therapy will depend on the development of drugs targeted at these putative pathophysiological mechanisms. On current evidence tricyclic antidepressants appear to be more effective than either acid suppressants or H. pylori eradication. (C) 2005 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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