Journal
JOURNAL OF DENTAL RESEARCH
Volume 84, Issue 8, Pages 711-714Publisher
INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R
DOI: 10.1177/154405910508400805
Keywords
caries; genetics; S. mutans; polymorphism; tuftelin
Categories
Funding
- NIDCR NIH HHS [R03 DE 014445-03, P60 DE 13076, R01 DE 014899, R01 DE014899, P30 DE 10126] Funding Source: Medline
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The purpose of this study was to identify genetic factors that contribute to dental caries susceptibility, either alone or in combination with environmental factors. Dental examinations were performed and buccal swab samples collected from 3- to 5-year-old children with at least 4 surfaces of decay, or with no evidence of decay. SNP assays for each of 6 candidate genes were performed for all cases and controls. Chi-square analysis and regression analysis were used for the evaluation of individual gene effects, environmental effects, and gene-environment interactions. There were no significant associations between single candidate genes and caries susceptibility. Levels of S. mutans were positively and Lactobacilli were negatively associated with caries. Regression analysis revealed a significant interaction between tuftelin and S. mutans, with 26.8% of the variation in dmfs explained by the interaction. Future research will focus on the identification of these additional factors and the development of functional assays so that these interactions can be better understood.
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