Journal
HUMAN REPRODUCTION
Volume 20, Issue 8, Pages 2325-2329Publisher
OXFORD UNIV PRESS
DOI: 10.1093/humrep/deh888
Keywords
aneuploidy; antinuclear antibody; bisphenol A; embryonic karyotype; recurrent miscarriage
Categories
Ask authors/readers for more resources
BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively. RESULTS: The mean +/- SD values for bisphenol A in patients were 2.59 +/- 5.23ng/ml, significantly higher than the 0.77 +/- 0.38ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage. CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available