Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 75, Issue 14, Pages 4919-4922Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00681-09
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- Ministry of Education, Culture, Sports, and Technology of the Japanese Government
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Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.
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