Journal
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Volume 59, Issue 8, Pages 988-991Publisher
WILEY
DOI: 10.1111/j.1368-5031.2005.00550.x
Keywords
carbamazepine; DRESS; hypersensitivity; liver failure; lymphocyte transformation
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Carbamazepine is a widely used drug. It is commonly associated with hepatic abnormalities, ranging from an asymptomatic rise in liver function tests to acute liver failure. The most severe reaction occurs as part of a generalised hypersensitivity reaction, also known as drug reaction, eosinophilia and systemic symptoms (DRESS). We describe a case of a young adult who presented with nonspecific symptoms, which progressed to fulminant hepatic failure, displaying the hallmarks of DRESS. We highlight the need for awareness of such an association.
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