Journal
NEUROIMAGING CLINICS OF NORTH AMERICA
Volume 15, Issue 3, Pages 639-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nic.2005.08.003
Keywords
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Funding
- NINDS NIH HHS [R01 NS386760, P01 NS35949] Funding Source: Medline
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Sodium MR imaging at 3.0 T provides high-quality images in acceptable acquisition times that allow assessment of tissue viability as defined by maintenance of sodium ion homeostasis. This application is made feasible for clinical stroke evaluation by an efficient projection pulse sequence with extremely short echo time values. This twisted projection imaging provides high signal-to-noise images at adequate resolution (5 X 5 X 5 mm(3)) in less than 10 minutes at 3.0 T. The images are quantified as tissue sodium concentration (TSC) maps that can be interpreted directly in terms of tissue viability. With infarction, baseline TSC values of less than 45 mmol/L increase at variable rates to approximately 70 mmol/L, allowing monitoring of the progression of stroke pathophysiology.
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