Journal
MOLECULAR NEUROBIOLOGY
Volume 32, Issue 1, Pages 51-57Publisher
SPRINGER
DOI: 10.1385/MN:32:1:051
Keywords
inflammation; stroke; cortical spreading depression; gene expression
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As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. Cortical spreading depression (CSD) is known to impart some degree of ischemic tolerance to the brain and to influence the expression of many genes. Many of the genes whose expression is altered by CSD are associated with inflammation, and it appears likely that modulation of the inflammatory response to ischemia by CSD contributes to ischemic tolerance. Understanding which inflammatory processes are influenced by CSD may lead to the identification of novel targets in the effort to develop an acute treatment for stroke.
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