Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 35, Issue 8, Pages 2416-2423Publisher
WILEY
DOI: 10.1002/eji.200526149
Keywords
HPEV1; TLR; endosomes; TLR7; TLR8
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Toll-like receptors (TLR) have a key role in regulating immunity against microbial agents. Engagement of TLR by bacterial, viral or fungal components leads to the production and release of inflammatory cytokines. In this study we show that mainly TLR8 and also TLR7 act as the host sensors for human parechovirus 1, a single-stranded RNA (ssRNA) virus. Furthermore, we see that the viral ssRNA genome is detected in endosomal compartments by these TLR, which activate signalling that lead to the synthesis of pro-inflammatory molecules by the host.
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