Journal
MOVEMENT DISORDERS
Volume 20, Issue 8, Pages 1052-1055Publisher
WILEY-LISS
DOI: 10.1002/mds.20501
Keywords
dopamine dysregulation syndrome; dopamine addiction; dyskinesia; STN DBS
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In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction. (c) 2005 Movement Disorder Society.
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