Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 206, Issue 1, Pages 73-93Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2004.11.006
Keywords
polycyclic aromatic hydrocarbons; heterocyclic aromatic compounds; chemical carcinogens; metabolic activation; DNA adducts; DNA damages
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Funding
- NIEHS NIH HHS [ES-04203-16A1] Funding Source: Medline
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Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic compounds (HACs) Constitute a major class of chemical carcinogens present in the environment. These Compounds require activation to electrophilic metabolites to exert their mutagenic or carcinogenic effects. There are three principal pathways currently proposed for metabolic activation of PAH and HAC: the pathway via bay region dihydrodiol epoxide by cytochrome P450 enzymes (CYPs), the pathway via radical cation by one-electron oxidation, and the ortho-quinone pathway by dihydrodiol dehydrogenase (DD). In addition to these major pathways, a brief description of a minor metabolic activation pathway, sulfonation, for PAHs that contain a primary benzylic alcoholic group or secondary hydroxyl group(s) is included in this review. The DNA damages caused through the reactive metabolites of PAH/HAC are described involving the DNA covalent binding to form stable or depurinating adducts, the formation of apurinic sites, and the oxidative damage. The review emphasizes the chemical/biochemical reactions involved in the metabolic processes and the chemical structures of metabolites and DNA adducts. (c) 2004 Elsevier Inc. All rights reserved.
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