Journal
BIOCHEMISTRY AND CELL BIOLOGY
Volume 83, Issue 4, Pages 418-428Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/O05-057
Keywords
nuclear hormone receptor; p160 family of coactivators; histone modification; chromatin remodeling complex
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The biological effects of hormones, ranging from organogenesis, metabolism, and proliferation, are transduced through nuclear receptors (NRs). Over the last decade, NRs have been used as a model to study transcriptional control. The conformation of activated NRs is favorable for the recruitment of coactivators, which promote transcriptional activation by directly communicating with chromatin. This review will focus on the function of different classes of coactivators and associated complexes, and on progress in our understanding of gene activation by NRs through chromatin remodeling.
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