Journal
TRENDS IN GENETICS
Volume 21, Issue 8, Pages 424-427Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2005.06.006
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Biochemists and geneticists, represented by Doug and Bill in classic essays, have long debated the merits of their methods. We revisited this issue using genomic data from the budding yeast, Saccharomyces cerevisiae, and found that genetic interactions outperformed protein interactions in predicting functional relationships between genes. However, when combined, these interaction types yielded superior performance, convincing Doug and Bill to call a truce.
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