4.6 Article

Molecular Characterization of a Variant of Bacillus anthracis-Specific Phage AP50 with Improved Bacteriolytic Activity

Journal

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 74, Issue 21, Pages 6792-6796

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01124-08

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Funding

  1. U. S. government [8.10084_08_NM_B]
  2. Finnish Centre of Excellence Program [1213467]

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The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype.

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