Journal
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
Volume 90, Issue 2, Pages 128-133Publisher
WILEY
DOI: 10.1016/j.ijgo.2005.05.005
Keywords
hormone therapy; estradiol valerate; dienogest; raloxifene; soy isoflavones; high-sensitive C-reactive protein
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Objective: To compare the effects of raloxifene, estradiol valerate plus dienogest, and soy isoflavones (genistein) on serum concentrations of high-sensitive C-reactive protein in healthy postmenopausal women. Methods: The 80 healthy postmenopausal women enrolled in the study were randomly allocated to receive 60 mg of raloxifene, 2 mg of estradiol valerate plus dienogest, 40 mg of genistein, or placebo (n = 20 in each group). Blood samples were collected at the start of the study and at 3 and 6 months. Lipid profile was also determined. Results: Only the group receiving estradiol valerate plus dienogest showed an increase in serum Levels of high-sensitive C-reactive protein compared with baseline values and values in the control and other groups. All 3 treatments resulted in an increase in high-density lipoprotein cholesterol levels and a decrease in total, tow-density, and very-low-density lipoprotein cholesterol levels. Conclusions: Estradiol valerate plus dienogest, but not raloxifene and genistein, increase serum high-sensitive C-reactive protein levels. All 3 treatments, however, have an estrogen-like effect on serum lipid profile. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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