Journal
CURRENT EYE RESEARCH
Volume 30, Issue 8, Pages 681-689Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/02713680590934102
Keywords
diabetic retinopathy; K5; macular edema; permeability; VEGF
Categories
Funding
- NEI NIH HHS [EY015650, EY12231] Funding Source: Medline
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Purpose: Increased retinal vascular permeability is a common complication of diabetes and a major cause of vision loss in diabetic patients. The current study is to determine the effect of plasminogen kringle 5 (K5) on vascular leakage via systemic and periocular deliveries. Methods: Oxygen-induced retinopathy (OIR) was generated by exposing newborn rats to 75% oxygen. Diabetes was induced in adult rats by injection of streptozotocin (STZ). Retinal vascular permeability was measured by the Evans blue-albumin leakage method. Results: Subcutaneous, intraperitoneal, subconjunctival, and retrobulbar injections and topical eyedrop application of K5 significantly reduced retinal vascular permeability in both the OIR and STZ-diabetic rat models. Compared with the periocular deliveries, systemic administration requires higher doses of K5. K5 deliveries downregulated VEGF expression in the retina. Conclusions: K5 can reduce retinal vascular permeability through systemic and periocular deliveries. These delivery routes of K5 have therapeutic potential in the treatment of vascular leakage.
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