Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 74, Issue 16, Pages 5250-5253Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00272-08
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A membrane-bound protein purified from Gluconobacter oxydans M5 was confirmed to be a pyrroloquinoline quinone-dependent D-sorbitol dehydrogenase. Gene disruption and complementation experiments demonstrated that this enzyme is responsible for the oxidation of 1-(2-hydroxyethyl) amino-1-deoxy-D-sorbitol (1NSL) to 6-(2-hydroxyethyl) amino-6-deoxy-L-sorbose (6NSE), which is the precursor of an antidiabetic drug, miglitol.
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