Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 31, Pages 11070-11075Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0504978102
Keywords
energy balance/obesity; host-microbial interactions; intestinal bacterial diversity; ob/ob mice; phylogenetics
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Funding
- NIDDK NIH HHS [T32 DK007130, DK 070977, DK 007130, R01 DK070977] Funding Source: Medline
- NIGMS NIH HHS [T32 GM142607, T32 GM008759] Funding Source: Medline
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We have analyzed 5,088 bacterial 16S rRNA gene sequences from the distal intestinal (cecal) microbiota of genetically obese ob/ob mice, lean ob/+ and wild-type siblings, and their ob/+ mothers, all fed the same polysaccharide-rich diet. Although the majority of mouse gut species are unique, the mouse and human microbiota(s) are similar at the division (superkingdom) level, with Firmicutes and Bacteroidetes dominating. Microbial-community composition is inherited from mothers. However, compared with lean mice and regardless of kinship, ob/ob animals have a 50% reduction in the abundance of Bacteroidetes and a proportional increase in Firmicutes. These changes, which are division-wide, indicate that, in this model, obesity affects the diversity of the gut microbiota and suggest that intentional manipulation of community structure may be useful for regulating energy balance in obese individuals.
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