Journal
CANCER LETTERS
Volume 226, Issue 1, Pages 85-90Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.12.030
Keywords
gastric carcinoma; lymphangiogenesis; VEGF-C; VEGF-D
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In this study, we investigated whether expression of vascular endothelial growth factor (VEGF)-C and/or VEGF-D correlates with clinicopathological features of human gastric carcinoma. We immunohistochemically examined the expression of VEGF-C and VEGF-D in 140 archival surgical specimens of submucosally invasive gastric carcinoma. Of these specimens, 32 (22.9%) and 12 (8.6%) showed intense VEGF-C and VEGF-D immunoreactivity in cancer cells, respectively. VEGF-C immunoreactivity was associated with histological type, lymphatic invasion, lymph node metastasis, and microvessel density. No association was identified between VEGF-D immunoreactivity and clinicopathological variables. These results suggest that VEGF-C is a dominant regulator of lymphangiogenesis in early-stage human gastric carcinoma. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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