How the T cell receptor sees antigen - A structural view

Structures of many of the cell surface receptor-ligand complexes mediating the interactions between T cells and target cells have been determined in the past ten years. While snapshots of T cell receptors bound to their peptide-MHC ligands appear to have defined a general interaction or docking solution, many of the most fundamental structural questions in antigen re cognition lack detailed answers and thus pose exciting experimental challenges for the future.