Journal
IMMUNOLOGY LETTERS
Volume 100, Issue 1, Pages 34-41Publisher
ELSEVIER
DOI: 10.1016/j.imlet.2005.06.017
Keywords
vitamin D receptor agonists; chronic allograft rejection; immunomodulation
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While immunosuppressive drugs now permit a good control of acute allograft rejection, chronic rejection remains an important unmet medical problem. We propose that Vitamin D receptor (VDR) agonists, secosteroid hormones that control cell proliferation and differentiation and exert immunoregulatory activities, in addition to regulate calcium and bone metabolism, have the potential to contribute to the management of chronic allograft rejection. Recent advances in understanding the immunomodulatory and growth-regulating properties of VDR agonists indicate the clinical applicability of these hormones in transplantation, with the aim of facilitating tolerance induction and preventing chronic graft rejection. (c) 2005 Elsevier B.V. All rights reserved.
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