Journal
BLOOD
Volume 106, Issue 4, Pages 1337-1340Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2005-01-0357
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Funding
- NIAID NIH HHS [R01AI20451] Funding Source: Medline
- NIGMS NIH HHS [GM07281] Funding Source: Medline
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Natural killer (NK) cells must be able to eliminate infected and transformed cells while remaining tolerant of normal cells. NK-cell self-tolerance is thought to be maintained by self-major histocompatibility complex (MHC) class I recognition; however, there are examples where NK cells are not regulated by MHC class I and yet remain self-tolerant. Here, we show that 2B4 (CD244) and CD48 represent a second system for murine NK-cell self-recognition. 2B4 and MHC class I receptors act nonredundantly to inhibit NK lysis of syngeneic tumor cells. NK cells from beta 2 microglobulin (beta 2m)-deficient mice and NK cells that lack expression of self-MHC-binding inhibitory receptors are inhibited by 2B4. Moreover, we provide the first in vivo evidence for MHC-independent NK self-recognition in a bone marrow rejection assay. These data suggest that NK-cell self-tolerance can be mediated by molecules other than MHC.
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