Journal
CLINICAL INFECTIOUS DISEASES
Volume 41, Issue 4, Pages E38-E41Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/432120
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Mutations in the interferon (IFN)-gamma receptor predispose to infection with bacille Calmette-Guerin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient with recurrent disseminated Histoplasma capsulatum osteomyelitis who had an autosomal dominant form of IFN-gamma receptor 1 deficiency (i.e., a 4-bp deletion at or near base 818). IFN-gamma-mediated immunity is important in the control of histoplasmosis.
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