Journal
SCIENCE
Volume 309, Issue 5738, Pages 1242-1245Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1114057
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The SAR11 clade consists of very small, heterotrophic marine alpha-proteobacteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomat elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.
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