Journal
SCIENCE
Volume 309, Issue 5738, Pages 1248-1251Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1116008
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Funding
- NIAID NIH HHS [AI053669, AI048704] Funding Source: Medline
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Most studies of host-pathogen interactions have focused on pathogen-specific virulence determinants. Here, we report a genome-wide RNA interference screen to identify host factors required for intracellular bacterial pathogenesis. Using Drosophila cells and the cytosolic pathogen Listeria monocytogenes, we identified 305 double-stranded RNAs targeting a wide range of cellular functions that altered L. monocytogenes infection. Comparison to a similar screen with Mycobacterium fortuitum, a vacuolar pathogen, identified host factors that may play a general role in intracellular pathogenesis and factors that specifically affect access to the cytosol by L. monocytogenes.
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