Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 100, Issue 1-2, Pages 72-79Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2005.05.011
Keywords
camptothecins; combretastatins; flavopiridol; podophyllotoxins; taxanes; vinca alkaloids; cell cycle target inhibitor
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Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide. derived froth epipodophyllotoxin, and paclitaxel (taxol(R)). A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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