Journal
CANCER LETTERS
Volume 226, Issue 2, Pages 101-106Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.11.053
Keywords
endometrial carcinoma; proteomics; SELDI-TOF-MS
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We have discovered several protein biomarkers that are altered during carcinogenesis of the human uterine endometrium. Proteins prepared from 19 endometrial carcinomas (Group A), and 20 normal endometria obtained from benign gynecological conditions (Group B), were investigated by Surface Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS). Two proteins, EC1 and EC2, were consistently expressed differentially. EC1 had an increased level of expression in carcinomas (P < 0.001), while EC2 was expressed at a lower level (P = 0.004). The isoelectric points of EC1 and EC2 were approximately pH 5.0 and 7.0, respectively. These proteins are thus potential biomarkers for detection of endometrial carcinoma. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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