Journal
STATISTICS IN MEDICINE
Volume 24, Issue 16, Pages 2477-2492Publisher
WILEY
DOI: 10.1002/sim.2124
Keywords
50 : 50 allocation; D-A-optimal design; ethics; inference; limiting proportion of allocation; minimization; randomization, regularization
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Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments. The adaptive design does not affect inference. Copyright (C) 2005 John Wiley & Sons, Ltd.
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