Journal
LUNG CANCER
Volume 49, Issue 3, Pages 395-400Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2005.04.001
Keywords
randomised trial; non-small cell lung cancer; neo-adjuvant chemotherapy; radical radiotherapy
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The majority of patients with stage T3, N1, M0 or T1-3, N2, M0 nonsmall cell lung cancer are considered inoperable, and receive radical radiotherapy. This randomised trial aimed to assess whether, in this group of inoperable patients, a policy of neo-adjuvant chemotherapy (with mitomycin, ifosfamide and cisplatin (MIC) or mitomycin, vinblastine and cisplatin (MVP)) followed, if feasible, by surgery (CT-S), would result in better outcomes than radical radiotherapy (RT). The trial closed due to poor accrual, with only 48 patients randomised in 3 years. Only 4 of the 24 patients in the CT-S group had a complete resection, and of these, the 2 patients who had a pneumonectomy both died 12 days after surgery. There was no evidence of an improved survival in the CT-S group (median survival 13.8 months, compared with 11.3 months for the RT group), but because the trial failed to recruit we were unable to reach any reliable conclusions about these two treatment options. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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