Journal
JOURNAL OF ENDOCRINOLOGY
Volume 186, Issue 3, Pages R7-R12Publisher
SOC ENDOCRINOLOGY
DOI: 10.1677/joe.1.06374
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This study investigated the effects of acute and chronic restraint stress during the third week of pregnancy on placental 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) activity in rats. Acute exposure to stress on gestational day 20 immediately up-regulated placental 11 beta-HSD2 activity by 160%, while chronic stress from day 14 to day 19 of pregnancy did not significantly alter basal 11 beta-HSD2 activity. However, the latter reduced the capacity to up-regulate placental 11 beta-HSD2 activity in the face of an acute stressor by 90%. Thus, immediate up-regulation of 11 beta-HSD2, the feto-placental barrier to maternal corticosteroids, may protect the fetus against stress-induced high levels of maternal corticosteroids, but exposure to chronic stress greatly diminishes this protection.
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