Journal
APOPTOSIS
Volume 18, Issue 8, Pages 917-924Publisher
SPRINGER
DOI: 10.1007/s10495-013-0845-3
Keywords
Outer mitochondrial membrane; Plant; Programmed cell death; Stress response; Voltage-dependent anion channel
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Funding
- Japan Society for the Promotion of Science [23780345]
- Grants-in-Aid for Scientific Research [23780345] Funding Source: KAKEN
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Voltage-dependent anion channels (VDACs), known as outer mitochondrial membrane proteins, are present in all eukaryotic cells. In mammals, they are now recognized to play crucial roles in the regulation of metabolic and energetic functions of mitochondria as well as in mitochondria-mediated apoptosis, in association with various proteins and non-protein modulators. Although there is much less information available for plant than for animal VDACs, their similar electrophysiological and topological properties suggest that some common functions are conserved among eukaryotic VDACs. Recently, it has been revealed that plant VDACs also have various important physiological functions not only in developmental and reproductive processes, but also in biotic and abiotic stress responses, including programmed cell death. In this review, we summarize recent findings about the sequence motifs, localization, and function of plant VDACs and discuss these results in the light of recent advances in research on animal VDACs.
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