Journal
JOURNAL OF PROTEOME RESEARCH
Volume 4, Issue 5, Pages 1781-1788Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr0501012
Keywords
copper; iron; intestine; proteomics; mass spectrometry; FABP; molecular chaperone; enolase; VDBP; filamin
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Copper and iron are cofactors of many metallo-proteins that accomplish vital functions, such as oxygen and electron transport. Specific metabolic pathways have been selected through evolution, although still not fully elucidated, to confine the dangerous reactivity of their free ionic forms. Inadequate supply of both metals can severly affect basic physiological funtions. A differential analysis of the rat intestinal proteome evidenced the following dietary copper- and iron-deficiencies, i.e., significant changes in the levels of proteins belonging to different functional classes (glucose and fatty acid metabolism, molecular chaperones, cytoskeleton plasticity, vitamin transporters). The presented results bring new perspectives to understand the role of copper and iron in the metabolic pathways and provide novel diagnostic tools to characterize the effects of subclinical deficiencies of both metals in unbalanced nutritional disorders.
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