Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 49, Issue 9, Pages 3966-3969Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.9.3966-3969.2005
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The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (C-trough) of > 4,300 ng/ml was found to predict longer VS. Patients with nevirapine C(trough)s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine Ctroughs below and above this concentration interval.
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