Journal
APOPTOSIS
Volume 15, Issue 9, Pages 1098-1113Publisher
SPRINGER
DOI: 10.1007/s10495-010-0478-8
Keywords
Clearance; MFG-E8; Biophysical features; Plasma membrane; Phosphatidylserine; HMGB-1; CRP; ANA
Categories
Funding
- Deutsche Forschungsgemeinschaft [HE 4490/3-1, SFB 643-project B5, SFB GK 643]
- Center for Clinical Research
- Friedrich-Alexander University
- Medical Faculty of the Friedrich-Alexander University [ELAN-fonds M3-09.03.18.1]
- K. und R. Wucherpfennigstiftung
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Systemic lupus erythematosus (SLE) is a complex disease resulting from inflammatory responses of the immune system against several autoantigens. Inflammation is conditioned by the continuous presence of autoantibodies and leaked autoantigens, e.g. from not properly cleared dying and dead cells. Various soluble molecules and biophysical properties of the surface of apoptotic cells play significant roles in the appropriate recognition and further processing of dying and dead cells. We exemplarily discuss how Milk fat globule epidermal growth factor 8 (MFG-E8), biophysical membrane alterations, High mobility group box 1 (HMGB1), C-reactive protein (CRP), and anti-nuclear autoantibodies may contribute to the etiopathogenesis of the disease. Up to date knowledge about these key elements may provide new insights that lead to the development of new treatment strategies of the disease.
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