Journal
JOURNAL OF BACTERIOLOGY
Volume 187, Issue 17, Pages 6094-6105Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.187.17.6094-6105.2005
Keywords
-
Categories
Ask authors/readers for more resources
pSM19035 of the pathogenic bacterium Streptococcus pyogenes is a low-copy-number plasmid carrying erythromycin resistance, stably maintained in a broad range of gram-positive bacteria. We show here that the omega-epsilon-zeta operon of this plasmid constitutes a novel proteic plasmid addiction system in which the E and genes encode an antitoxin and toxin, respectively, while omega plays an autoregulatory function. Expression of toxin Zeta is bactericidal for the gram-positive Bacillus subtilis and bacteriostatic for the gram-negative Escherichia coli. The toxic effects of gene expression in both bacterial species are counteracted by proper expression of F. The epsilon-zeta toxin-antitoxin cassette stabilizes plasmids in E. coli less efficiently than in B. subtilis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available