Journal
BIOCHEMISTRY-MOSCOW
Volume 70, Issue 9, Pages 1065-1069Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1007/s10541-005-0225-x
Keywords
T-cells; transcription factor GATA-3; interleukin-4; promoter; repressor
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GATA-3 was shown to bind to two sites of the IL-4 gene promoter in human T-cell lines PER-I 17 and Jurkat. A motif located in the region of position -860 and responsible for GATA-3 binding was detected for the first time. Mutation or deletion of this site increased the promoter activity. The findings suggest a direct involvement of GATA-3 in regulation of the human IL-4 gene transcription as a repressor of the promoter activity.
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