Journal
APOPTOSIS
Volume 14, Issue 4, Pages 607-623Publisher
SPRINGER
DOI: 10.1007/s10495-009-0321-2
Keywords
TRAIL; Apoptosis; Cancer therapy; TRAIL resistance
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Inducing apoptosis has become an important approach in the development of new anti-cancer treatments. Tumour necrosis factor apoptosis inducing ligand (TRAIL) based therapies have emerged as one of the most promising examples of this as they selectively induce apoptosis in tumour cells. However, many primary tumours are inherently resistant to TRAIL-mediated apoptosis and require additional sensitisation. Here we review apoptotic and non-apoptotic TRAIL-signalling, and the therapeutic effects of TRAIL-based treatments both as monotherapy and in combination with sensitising agents.
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