Journal
APOPTOSIS
Volume 14, Issue 4, Pages 424-438Publisher
SPRINGER
DOI: 10.1007/s10495-009-0325-y
Keywords
Medulloblastoma; Neuroblastoma; Apoptosis; Mitochondria; Novel therapy
Categories
Funding
- Swedish Cancer Society
- Swedish Research Council
- Swedish Childhood Cancer Society
- King Gustaf V Jubilee Foundation
- Karolinska Institutet
- KICancer
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Medulloblastoma and neuroblastoma are malignant embryonal childhood tumours of the central and peripheral nervous systems, respectively, which often show poor clinical prognosis due to resistance to current chemotherapy. Both these tumours have deficient apoptotic machineries adopted from their respective progenitor cells. This review focuses on the specific background for tumour development, and highlights biological pathways that present potential targets for novel therapeutic approaches.
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