Journal
PLANTA MEDICA
Volume 71, Issue 9, Pages 835-840Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-871297
Keywords
Flemingia macrophylla; Leguminosae; flavonoids; neuroprotection
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Using an A beta-induced neurotoxicity blocking assay to direct fractionation, three new flavonoids, fleminginin (1), flemingichromone (2), and flemingichalcone (3), and twenty known compounds were isolated from the active fractions of the aerial parts of Flemingia macrophylla. The structures of 1 - 3 were elucidated on the basis of spectroscopic data. When tested for neuroprotective activity, compound 2, osajin (4), 5,7,4 -trihydroxy-6,8-dipre-nylisoflavone (5), 5,7,4'-trihydroxy-6,3-diprenylisoflavone(6), and aureole (7) protected neuronal cells from A beta-induced damage with EC50 values of 31.43 +/- 3.16, 5.01 +/- 1.28,11.25 +/- 1.51, 4.47 +/- 0.65,12.09 +/- 2.55 mu M, respectively.
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