Journal
ORGANIC LETTERS
Volume 7, Issue 18, Pages 3829-3832Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol051110j
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(S)-2-[(R)-Fluoro(phenyl)methyl]oxirane is a new, synthetic, yet enantiopure, chiral resolution reagent, readily obtained from enantiopure (2S,3S)-phenylglycidol, that reacts with a variety of alpha-chiral primary and secondary amines in a straightforward manner through a regioselective ring-opening. Diastereomeric products are easily identified and quantified by F-19, H-1, and C-13 NMR and by HPLC, which makes this fluorinated compound a most versatile reagent for the analysis of scalemic mixtures of amines.
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