Journal
JOURNAL OF LIPID RESEARCH
Volume 46, Issue 9, Pages 1896-1903Publisher
ELSEVIER
DOI: 10.1194/jlr.M400504-JLR200
Keywords
bioavailability; vitamin A; liquid chromatography-mass spectrometry; Brassica oleracea
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The bioavailability of carotenoids from kale was investigated by labeling nutrients in kale with C-13, feeding the kale to seven adult volunteers, and analyzing serial plasma samples for labeled lutein, beta-carotene, and retinol. Ingested doses of labeled carotenoids were 34 mu mol for beta-carotene and 33 mu mol for lutein. Peak plasma concentrations, areas under the plasma concentration-time curves (AUCs), and percentages of dose recovered at peak plasma concentrations were calculated. Average peak plasma concentrations were 0.38, 0.068, and 0.079 mu M for [C-13]lutein, [C-13] beta-carotene, and [C-13]retinol, respectively. Average AUC values (over 28 days) were 42.8, 13.6, 13.2 mu M h for [C-13]lutein, [C-13]beta-carotene, and [C-13]retinol, respectively. Percentages of dose recovered at peak plasma concentrations were 3.6, 0.7, and 0.7% for [C-13]lutein, [C-13]beta-carotene, and [C-13]retinol, respectively. A positive relationship was observed between baseline plasma retinol levels and [C-13]retinol plasma response. It is possible that this relationship was mediated either through some aspect of beta-carotene absorption or via the common pathways of metabolism for postdose and endogenous retinoid.
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