Journal
NANO LETTERS
Volume 5, Issue 9, Pages 1698-1703Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0509125
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Funding
- NIGMS NIH HHS [R01 GM038147, R01 GM038147-14S1, GM38147] Funding Source: Medline
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Controlled movement of materials or molecules within the nanometer range is essential in many applications of nanotechnology. Here we report the capture, movement, and release of cargo molecules along DNA by a modified form of T7 RNA polymerase (RNAP) in a manner that is controlled by the sequence of the DNA. Using single-molecule methods, we visualize the assembly and manipulation of nanodevices and the ability to harness rotary and linear forces of the RNAP motor.
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