Journal
NATURE IMMUNOLOGY
Volume 6, Issue 9, Pages 938-945Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1236
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Funding
- NCI NIH HHS [R01 CA095137, CA95137] Funding Source: Medline
- NIDDK NIH HHS [P30 DK026743, P30-DK26743] Funding Source: Medline
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Irradiation- resistant natural killer ( NK) cells in an F-1 recipient can reject parental bone marrow, and host NK cells can also prevent engraftment of allogeneic bone marrow. We show here that repopulating bone marrow cells in certain mouse strains expressed retinoic acid early inducible 1 proteins, which are ligands for the activating NKG2D NK cell receptor. Treatment with a neutralizing antibody to NKG2D prevented rejection of parental BALB/ c bone marrow in ( C57BL/ 6 x BALB/ c) F1 recipients and allowed engraftment of allogeneic BALB. B bone marrow in C57BL/ 6 recipients. Additionally, bone marrow from C57BL/ 6 mice transgenic for retinoic acid early inducible 1 epsilon was rejected by syngeneic mice but was accepted after treatment with antibody to NKG2D. If other stem cells or tissues upregulate expression of NKG2D ligands after transplantation, NKG2D may contribute to graft rejection in immunocompetent hosts.
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