Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 28, Issue 9, Pages 1042-1046Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/BF02977399
Keywords
marine-derived fungus; Spicaria elegans; trichodermamide A (penicillazine); aspergillazine A; modified dipeptides; cytotoxic activity
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Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
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