Journal
JOURNAL OF VIROLOGY
Volume 79, Issue 17, Pages 11507-11512Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.17.11507-11512.2005
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Funding
- NCRR NIH HHS [P20 RR17708, P20 RR017708] Funding Source: Medline
- NIAID NIH HHS [R21 AI059328, AI059328, U54 AI057160] Funding Source: Medline
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The nucleocapsid (N) protein of several members within the order Nidovirales localizes to the nucleolus during infection and after transfection of cells with N genes. However, confocal microscopy of N protein localization in Vero cells infected with the severe acute respiratory syndrome coronavirus (SARS-CoV) or transfected with the SARS-CoV N gene failed to show the presence of N in the nucleoplasm or nucleolus. Amino acids 369 to 389, which contain putative nuclear localization signal (NLS) and nucleolar localization signal motifs, failed to restore nuclear localization to an NLS-minus mutant Rev protein. These data indicate that nuclear localization is not a conserved property among all nidoviruses.
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