Journal
FITOTERAPIA
Volume 76, Issue 6, Pages 549-555Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2005.04.014
Keywords
embelin; curcumin; N-nitrosodiethylamine; phenobarbital; hepatocarcinogenesis
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The effects of embelin (50 mg/kg/day), a benzoquinone derivative of Embelia ribes, and the effects of curcumin (100 mg/kg/day), the active principle of Curcuma longa, against N-nitrosodiethylamine (DENA)-initiated and phenobarbital (PB)-promoted hepatocarcinogenesis were studied in Wistar rats. They were able to prevent the induction of hepatic hyper plastic nodules, body weight loss, increase in the levels of hepatic diagnostic markers, and hypoproteinemia induced by DENA/PB treatment. Hence, results of our study suggest the possible chemopreventive effects of embelin (EMB) and curcumin (CUR) against DENA/PB-induced hepatocarcinogenesis in Wistar rats. (c) 2005 Published by Elsevier B.V.
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