Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 28, Issue 9, Pages 1795-1797Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.28.1795
Keywords
salvia miltiorrhiza; Labiatae; protein tyrosine phosphatase 1B (PTP1B) inhibitor; isotanshinone IIA; dihydroisotanshinone I; isocryptotanshinone
Categories
Ask authors/readers for more resources
Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of Salvia miltiorrhiza BUNGE (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone 1 (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4 +/- 0.6 mu M, 22.4 +/- 0.6 mu M and 56.1 +/- 6.3 mu M, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available