Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 54, Issue 3, Pages 507-512Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.20605
Keywords
3 T; magnetization transfer; T-1; T-2; MTR; liver; cartilage; muscle; heart; spinal cord; kidney; white matter; gray matter; blood
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T-1, T-2, and magnetization transfer (MT) measurements were performed in vitro at 3 T and 37 degrees C on a variety of tissues: mouse liver, muscle, and heart; rat spinal cord and kidney; bovine optic nerve, cartilage, and white and gray matter; and human blood. The MR parameters were compared to those at 1.5 T. As expected, the T2 relaxation time constants and quantitative MT parameters (MT exchange rate, R, macromolecular pool fraction, M-0B, and macromolecular T-2 relaxation time, T-2B) at 3 T were similar to those at 1.5 T. The T, relaxation time values, however, for all measured tissues increased significantly with field strength. Consequently, the phenomenological MT parameter, magnetization transfer ratio, MTR, was lower by approximately 2 to 10%. Collectively, these results provide a useful reference for optimization of pulse sequence parameters for MRI at 3 T.
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